Dr. Nestler laboratory studies the molecular mechanisms of drug addiction and depression in animal models. Here they focus on the molecular and cellular changes that occur in regions of the brain important for reward and motivation, in response to chronic administration of a drug of abuse or chronic exposure to stress. He has a particular interest in long-lasting changes, that are mediated via alterations in gene expression and chromatin remodeling. His goal is to achieve results that will guide future efforts toward the development of more effective treatments for addiction and depression.
Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., … Han, M.-H. (2013). Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature, 493(7433), 532–6. doi:10.1038/nature11713
Russo, S. J., Murrough, J. W., Han, M.-H., Charney, D. S., & Nestler, E. J. (2012). Neurobiology of resilience. Nature neuroscience, 15(11), 1475–84. doi:10.1038/nn.3234
Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J. (2013). Epigenetic mechanisms of depression and antidepressant action. Annual review of pharmacology and toxicology (Vol. 53, pp. 59–87). doi:10.1146/annurev-pharmtox-010611-134540