2011 TC Research
Teachers College, Columbia University
Teachers College Columbia University

Research

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John Thomas Pinto

Professional Background

Educational Background

B.S. (Chemistry), St. John Fisher College, Rochester, NY, 1968
Ph.D., (Biochemistry), University of Medicine and Dentistry of NJ, 1974

Scholarly Interests

Interactions of drugs and nutrients; the impact of phytochemicals, herbs and drugs on human health and disease.

Selected Publications

Selected Peer-Reviewed Publications (2006-2008)

Pinto JT, Krasnikov BF, and Cooper AL.  Redox-sensitive proteins are potential targets of garlic-derived mercaptocysteine derivatives. J. Nutr, 136:835S-841S, 2006.

El-Bayoumy K, Sinha R, Pinto JT, and Rivlin RS.  Cancer Chemoprevention by garlic and garlic-containing sulfur and selenium compounds.  J. Nutr, 136:864S-869S, 2006.

Cooper AJL and Pinto, JT.  Cysteine S-conjugate b-lyases.  Amino Acids,  30:1-15, 2006.

Cho S, Szeto HH, Kim E., Kim HJ, Tolhurst A, and Pinto JT.  A novel cell permeable antioxidant peptide, SS31, attenuates ischemic brain injury by down-regulating CD36.
J Biol Chem. 282(7):4634-42. 2007.

Pinto JT, Sinha R, Papp K, Facompre ND, Desai D, and El-Bayoumy K.  Differential effects of naturally occurring and synthetic organoselenium compounds on biomarkers in androgen responsive and androgen independent human prostate carcinoma cells. Int J Cancer. 120(7):1410-1417, 2007.

Sinha R, Pinto JT, Facompre N, Kilheffer J, Baatz JE, and El-Bayoumy K. Effects of naturally occurring and synthetic organoselenium compounds on protein profiling in androgen responsive and androgen independent human prostate cancer cells.  In Press:  Nutr Cancer, 2008.

Huang Z, Pinto JT, Deng H, and Richie JP, Jr. Inhibition of Caspase-3 Activity and Activation by Protein Glutathionylation.  In Press: Biochem Pharm, 2008.

biographical information

John Thomas Pinto is Professor of Biochemistry and Molecular Biology at New York Medical College in Valhalla, New York. His training in Nutritional Biochemistry began in 1974 at the Institute of Human Nutrition, Columbia University. In 1980, he joined the staff at Memorial Sloan-Kettering Cancer Center (MSKCC) as Assistant Laboratory Member and was appointed Assistant Professor of Nutrition in Medicine, Weill Medical College of Cornell University in New York City.  During that time (1980-83), he was awarded the Future Leader's Award from the Nutrition Foundation. From 1989 until 1996, he was co-director of the Clinical Nutrition Research Unit (CNRU) Metabolism and Oncology Core Laboratory at MSKCC and until 2002, also directed the Nutrition Research Laboratory.  In 2002 to 2004, he was Senior Research Scientist at the Institute for Cancer Prevention (Formerly, the American Health Foundation) until its closure and then joined the staff at the Cornell-Burke Medical Research Institute in White Plains, New York.  In 2007, he joined the faculty at New York Medical College in his current rank as Professor of Biochemistry and Molecular Biology.  His teaching experiences in vitamin and mineral metabolism and drug-nutrient interactions have extended to programs at New York University, University of New Haven, The Institute of Human Nutrition (Columbia University), New York Medical College, and Teachers College in the Department of Health and Behavior Studies.  He is a member of The American Institute of Nutrition, The American Society for Clinical Nutrition, and the American Association for Cancer Research.  Dr. Pinto also serves as a reviewer for the American Journal of Clinical Nutrition, Biochemical Pharmacology, Biochemical Journal, Nutrition and Cancer, the Journal of Nutrition, and Analytical Biochemistry.  His research focuses on the effects of chemopreventive agents, dietary factors, and xenobiotic substances on modifying oxidation/reduction capacity in human cells and tissueS. In particular, his studies examine mechanisms of S-allylsulfides, S-cysteinyl and organoselenium compounds from allium foods (garlic, onion) that alter antioxidant enzyme systems and cytosolic signal proteins which affect proliferative and apoptotic processes within human prostate cancer cells.

HBSV 5011: Advanced nutrition II

In-depth review of current knowledge and research on the biochemical and physiological aspects of vitamins, minerals, and phytonutrients; applications to diet.