Gordon, Andrew M. (ag275)

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Gordon, Andrew
Professor of Movement Sciences
Movement Science Program Coordinator
Biobehavioral Sciences
212-678-3326

Office:
1056E Thndk

Educational Background

B.A., Hampshire College

M.S., Pennsylvania State University

Ph.D., Karolinska Institute

Postdoctoral Fellow, University of Minnesota.

Scholarly Interests

I have a broad background in neurophysiology and biomechanics and have extensive clinical and research expertise involving motor learning and development in typically developing children and children with cerebral palsy. Our team has been studying hand motor control in healthy individuals and individuals with cerebral palsy (CP) for over 25 years. In a line of basic research funded by the National Science Foundation, we have been elucidating the nature of internal models underlying object manipulation by studying fingertip forces and positions during object manipulation.

 

In 1996 I founded the Center for Cerebral Palsy Research (http://www.tc.columbia.edu/cit/). The Center consists of a unique team of scientists and clinicians, and is committed to improving the lives of children with CP through research and education, with an emphasis on understanding the mechanisms underlying motor disorders associated with CP, and developing evidence-based treatment approaches targeting these disorders. Our initial studies on grip force planning and modulation during object manipulation showed that children with CP 1) show improvements in grasping during development, and 2) benefit from extensive practice. Thus, hand function is not static, and is amenable to improvement.

 

Our first approach to providing extensive practice was modifying constraint-induced movement therapy (CIMT) for children with CP. In 2001 we published the first study on modified CIMT in children with unilateral CP. Subsequently in a line of work supported by the National Institute of Health, we more broadly studied the efficacy of CIMT. We used CIMT as the basis for creating a highly structured and intensive form of bimanual therapy, Hand-Arm Bimanual Intensive Therapy (HABIT), and have conducted several trials indicating efficacy in improving upper extremity function. Since 2002 more than 300 children with CP have participated in our hand treatment day camps. We subsequently collaborated with a team in Belgium to modify HABIT to target both the upper and lower extremity of children with unilateral and bilateral CP. We have been using transcranial magnetic stimulation (TMS) to study the neuroplasticity associated with such intensive training and discovered that skill progression was a key ingredient to drive cortical plasticity, improve goal performance and movement coordination. Recent work has been using TMS and diffusor tensor imaging to study whether specific patterns of brain connectivity predict response to CIMT and HABIT, and the role of sensory systems in hand function and recovery in children with CP.



Selected Publications

Complete List of Published Work:

 

http://www.ncbi.nlm.nih.gov/sites/myncbi/andrew.gordon.1/bibliography/49708537/public/?sort=date&direction=descending

 

Select publications

 

Marneweck, M, Kuo, H-C, Smorenburg, ARP, Ferre, CL, Flamand, VH, Gupta, D, Carmel, JB, Bleyenheuft, Y, Gordon, AM, Friel, KM. (2018) The relationship between hand function and overlapping motor representations of the hands in the contralesional hemisphere in unilateral spastic cerebral palsy. Neural Rehabilitation and Neural Repair 32:62-72.

 

Kuo, H-C, Friel, KM, Gordon, AM (2018) Neurophysiological Mechanisms and Functional Impact of Mirror Movements in Children with Unilateral Spastic Cerebral Palsy. Developmental Medicine and Child Neurology 60:155-161.

 

Ferre, CL, Brandao, M, Surana, B, Dew, AP, Moreau, NG, Gordon, AM. (2017) A Randomized Trial of Caregiver-directed Home-based Intensive Bimanual Training in Young Children with Unilateral  Spastic Cerebral Palsy. Developmental Medicine and Child Neurology 59: 497-504.

 

Smorenburg, ARP, Gordon, AM, Kuo, HC, Ferre, CL, Brandao, M, Bleyenheuft, Y, Carmel, JB, Friel, KM. (2017) Does corticospinal tract connectivity influence the response to intensive bimanual therapy in children with unilateral cerebral palsy. Neural Rehabilitation and Neural Repair 31: 250-260.

 

Bleyenheuft, Y, Ebner-Karestinos, D, Surana, B, Paradis, J, Sidiropoulos, A, Renders, A, Friel, KM, Brandao, M, Rameckers, E, Gordon, AM (2017) Intensive upper and lower extremity training for children with bilateral cerebral palsy: A quasi-randomized trial. Developmental Medicine and Child Neurology 59: 625-633.

 

Bleyenheuft, Y, Ebner-Karestinos, D, Surana, B, Paradis, J, Sidiropoulos, A, Renders, A, Friel, KM, Brandao, M, Rameckers, E, Gordon, AM (2017) Intensive upper and lower extremity training for children with bilateral cerebral palsy: A quasi-randomized trial. Developmental Medicine and Child Neurology 59: 625-633.

 

Kuo, H-C, Ferre, CL, Carmel, JB, Gowatsky, JL, Stanford, AD, Rowny, SB, Lisanby, SH, Gordon, AM, Friel, KM. (2017) Using diffusion tensor imaging to identify corticospinal tract projection patterns in children with unilateral spastic cerebral palsy. Developmental Medicine and Child Neurology 59: 65-71.

 

Marneweck, M, Lee-Miller, T, Santello, M, Gordon, AM. (2016) Digit Position and Forces Covary During Anticipatory Control of Whole-Hand Manipulation. Frontiers in Human Neuroscience 10:461.

 

Lee, T, Marneweck, M, Santello, M, Gordon, AM. (2016) Visual cues of object properties differentially affect anticipatory planning of digit forces and placement. PLOS One. 11(4):e0154033.

 

Bleyenheuft, Y, Arnould,C, Brandao, MB, Bleyenheuft, C, Friel, K, Kuo, H-C M, Ferre, CL, Brandao, M, Carmel, J, Bleyenheuft, Y, Gowatsky, JL, Stanford, AD, Rowny, SB, Luber, B, Bassi, B, Murphy, DLK, Lisanby, SH, Gordon, AM (2016) Skilled bimanual training drives motor cortex plasticity in children with unilateral cerebral palsy. Neural Rehabilitation and Neural Repair 30: 834-844.

 

Gordon, AM (2015) Hand and Arm Bimanual Intensive Therapy Including Lower Extremity (HABIT-ILE) in Children With Unilateral Spastic Cerebral Palsy: A Randomized Trial. Neural Rehabilitation and Neural Repair 29:  645–657.

 

Bleyenheuft, Y, Arnould,C, Brandao, MB, Bleyenheuft, C, Gordon, AM (2015) Hand and Arm Bimanual Intensive Therapy Including Lower Extremity (HABIT-ILE) in Children With Unilateral Spastic Cerebral Palsy: A Randomized Trial. Neural Rehabilitation and Neural Repair 29:  645–657.

Brandao, M, Ferre, CL, Kuo, H-C, Rameckers, E, Bleyenheuft, Y, Hung, Y-C, Friel, K, Gordon, AM (2014) Comparison of structured skill and unstructured practice during intensive bimanual training in children with unilateral spastic cerebral palsy. Neural Rehabilitation and Neural Repair 28: 452-461.

 

Gordon, A.M., Hung, Y.C., Brandao, M., Ferre, C.L., Kuo, H.C., Friel, K., Petra, E., Chinnan, A., Charles, J.R. (2011). Bimanual training and Constraint-Induced Movement Therapy in children with hemiplegic cerebral palsy: A Randomized Trial. Neurorehabilitation and Neural Repair, 25(8), 692-702.

 

Society for Neuroscience

International Brain Research Organization

Society for the Neural Control of Movement

American Academy for Cerebral Palsy and Developmental Medicine

National Science Foundation (2008-2011)

Principle Investigator, “Dexterous Control of Multi-Digit Grasping

 

National Institutes of Health (2009-2014)

Sponsor (K01 Trainee: Kathleen Friel)

 

National Institutes of Health (2008-2009)

Sponsor (K12 Trainee: Kathleen Friel)

 

Thrasher Foundation (2007-2010)

Principle Investigator, “A Randomized Control Trial of Hand-Arm Intensive Bimanual”

 

National Science Foundation (2006-2009)

Principle Investigator, “Coordination of multi-digit forces during grasping”


National Institutes of Health, K23 (2006-2011)
Sponsor (K-award Trainee: Preeti Raghaven) 
 

United Cerebral Palsy Research and Education Foundation (2005-2008)

Principal Investigator. “Rehabilitative strategies for improving unimanual and bimanual hand function in children with hemiplegic CP”

 

NIH National Research Service Award

Dissertation Fellowship, Karolinska Institute

 
Fulbright Award
AACPDM Richmond Cerebral Palsy Research Award Nomination
APTA Hughs Award for best pediatric research paper with a physical therapist/student co-author
 
Best Paper Award, Foundation for Physical Medicine & Rehabilitation
 
2007 Gayle Arnold Award for Best Scientific Paper (with Jeanne Charles) from the American Academy for Cerebral Palsy and Developmental Medicine

Zhang, W, Gordon, AM, Fu, Q, Santello, M, Object rotation reveals independent sensorimotor

    memory representations of digit positions and forces for skilled manipulation. Journal of

    Neurophysiology (In Press).

 

Raghaven, P, Santello, M, Gordon, AM, Krakauer, J, Compensatory motor control After Stroke:

    an alternative joint strategy for object-dependent shaping of hand posture. Journal of

    Neurophysiology (In Press).

 

Diermayr, G, Gordon, AM, Grasp control underlying manual dexterity in the elderly.

    Gerontology (In Press).

 

Albert, F, Diermayr, GD, McIsaac, TL, Gordon, AM, Coordination of grasping and walking in

    Parkinson's disease. Experimental Brain Research (In Press)

 

Nilsen, DM, Gillen, G, Gordon, AM. The use of mental practice to improve upper limb recovery

    post-stroke: A systematic review. American Journal of Occupational Therapy. (In Press).

 

Rabin, E, Muratori, LM, Svokos, K, Gordon, A (2010) Tactile/proprioceptive integration

    during arm localization is intact in individuals with Parkinson's disease. Neuroscience Letters

    470: 38-42.

 

Hung, YC, Charles, J, Gordon, AM (2010) Influence of Accuracy Constraints on Bimanual

    Coordination during a Goal-Directed Task in Children with Hemiplegic Cerebral Palsy.

    Experimental Brain Research 201:421-428.

 

Albert, F, Santello, M, Gordon, AM, (2009) Sensorimotor Memory of Object Weight

    Distribution during Multidigit. Neuroscience Letters 463: 188–193.

 

Steenbergen,B, Crajé, C,  Nilsen, DM, Gordon, AM (2009) Motor imagery training in

    hemiplegic cerebral palsy: A potentially useful therapeutic tool for rehabilitation

    Developmental Medicine and Child Neurology 51: 690–696.

 

Montes, J,  Gordon, AM,  Pandya, S,  De Vivo, DC,  Kaufmann P (2009) Clinical Outcome

   Measures in Spinal Muscular Atrophy (SMA). Journal of Child Neurology 24: 968-978.

 

McIsaac, TL, Johnston, JA, Santello, M, Zhang, W, Gordon, AM (2009) Task-specific

    modulation of multi-digit forces to object texture. Experimental Brain Research 194: 79-90.

 

Gordon, AM, Chinnan, A, Gill, S, Petra, E, Hung, YC, Charles, J (2008) Both constraint-induced

    movement therapy and bimanual training lead to improved performance of upper extremity

    function in children with hemiplegia. Developmental Medicine and Child Neurology

    50:  957-958.

 

Gordon, AM, Steenbergen, B. (2008) Bimanual coordination in children with cerebral palsy: In: AC Eliasson and P. Burtner (Eds.) Improving Hand Function in Children with Cerebral Palsy:

    Theory, evidence and intervention. Clinics in Developmental Medicine, London: MacKeith

    Press pp. 160-175.

 

Eliasson, AC, Gordon, AM. (2008) Constraint-Induced Movement Therapy for Children with

    Hemiplegia. In: AC Eliasson and P. Burtner (Eds.) Improving Hand Function in Children with

    Cerebral Palsy: Theory, evidence and intervention. Clinics in Developmental Medicine,

    London: MacKeith Press, pp. 308-319.


 

Gordon, AM, Chinnan, A, Gill, S, Petra, E, Hung, YC, Charles, J (2008) Both constraint-induced

    movement therapy and bimanual training lead to improved performance of upper extremity

    function in children with hemiplegia. Developmental Medicine and Child Neurology

    50:  957-958.

 

Gysin, P, Kaminski, TR, Hass, CJ, Gordon AM (2008) Effects of gait variations on grip force

    coordination during object transport. Journal of Neurophysiology 100: 2477-2485.

 

Diermayr, G, Gysin, P, Hass, CJ, Gordon AM (2008) Grip force control during gait initiation

    with a hand-held object. Experimental Brain Research 190: 337-345.

 

Steenbergen, B, Charles, J, Gordon, AM (2008) Fingertip force control during bimanual object

    lifting in hemiplegic cerebral palsy. Experimental Brain Research 186: 191-201.

 

Majsak, M, Kaminski, T, Gentile, AM, Gordon, AM (2008) Effects of a moving target versus a

    temporal constraint on reach and grasp in patients with Parkinson’s disease Experimental

    Neurology 210: 479-88.

 

Muratori, L, McIsaac, T, Gordon, AM, Santello, M (2008), Impaired Anticipatory Control of

    Force Sharing Patterns during Whole-Hand grasping in Parkinson Disease Experimental Brain

    Research 185: 41-52.

 

Gordon, AM, Charles, J, Schneider, JA, Chinnan, A, (2007) Efficacy of a Hand-Arm bimanual

    intensive therapy (HABIT) for Children with Hemiplegic Cerebral Palsy: A Randomized

    Control Trial. Developmental Medicine and Child Neurology 49: 830-838.

 

Charles, JC, Gordon, AM (2007) A repeated course of constraint-induced movement therapy

    results in further improvement.. Developmental Medicine and Child Neurology 49:770-773.

 

Steenbergen, B, Verrel, J, Gordon, AM. (2007) Motor planning in congenital hemiplegia Disability Research 29: 13-23.

 

Gordon, AM, Steenbergen, B, Charles, J (2006) Movement planning is disrupted by impaired sensorimotor integration in children with hemiplegic cerebral palsy. Pediatric Research 60: 587-91.

 

Steenbergen, B, Gordon, AM (2006) Activity limitation in Cerebral Palsy:  Evidence for disorders in motor planning Developmental Medicine and Child Neurology 48: 780-783.

 

Charles, J, Gordon, AM (2006) Development of Hand-Arm Bimanual Intensive Therapy (HABIT) for Improving Bimanual Coordination in Children with Hemiplegic Cerebral Palsy. Developmental Medicine and Child Neurology 48:931-936.

 

Eliasson, AC, Forssberg, H, Hung, YC, Gordon, AM (2006) Development of Hand Function and Precision Grip Control in Individuals with Cerebral Palsy: A 13-Year Follow Up Study. Pediatrics 118:e1226-236.

 

Muratori, L, Depaul, G, Gordon, AM (2006) Effect of Object Transport on Grasp Coordination in Multiple System Atrophy. Movement Disorders 21:555-63.

 

Charles, J, Wolf, SL, Schneider, JA, Gordon, AM (2006) Efficacy of a Child-Friendly Form of  Constraint-Induced Movement Therapy in Hemiplegic Cerebral Palsy: A Randomized Control Trial. Developmental Medicine and Child Neurology 48:635-642.

 

Gordon, AM, Charles, J, Wolf, SL (2006) Efficacy of Constraint-Induced Movement Therapy on Involved-Upper Extremity Use in Children with Hemiplegic Cerebral Palsy is not Age-Dependent. Pediatrics 117:e363-373.

 

Rabin, E, Gordon, AM (2006) Tactile and muscle spindle cues are interpreted based on joint-specific feedback from prior experience and current movement goals" Experimental Brain Research 169:407-16.

 

Raghaven, P, Krakauer, JW, Gordon, AM (2006) Impaired anticipatory control of fingertip forces in patients with a pure motor or sensorimotor lacunar syndrome. Brain 129:1415-1425.

 

Raghaven, P, Petra, E, Krakauer, J, Gordon, AM (2006) Patterns of impairment in digit independence after subcortical stroke. Journal of Neurophysiology 95:369-78.

 

Charles, J, Gordon, AM, (2005) A critical review of constraint-induced movement therapy and forced-use in children with hemiplegia. Neural Plasticity 12: 245-261.

 

Lamberg, E, Mateika, JM, Gordon, AM (2005) Visual properties of objects affect manipulative forces and respiration differently. Brain Research 1066:158-63.

 

Grigos, MI, Saxman, J, Gordon, AM (2005) Speech motor development during acquisition of the voicing contrast. Journal of Speech, Language, and Hearing Research 48:739-52.

 

Gordon, AM, Charles, J, Wolf, SL (2005) Methods of Constraint-induced Movement Therapy for Children with Hemiplegic Cerebral Palsy: Development of a Child-friendly Intervention for Improving Upper Extremity Function. Archives of Physical Medicine and Rehabilitation

    86:837-44.

 

 

Courses

Related Articles

TC's Andrew Gordon is Honored by the National Academy of Kinesiology

Andrew Gordon, Professor of Movement Sciences and Director of TC's Center for Cerebral Palsy Research, has been elected an Active Fellow in the National Academy of Kinesiology (NAK).

/articles/2012/may/tcs-andrew-gordon-is-honored-by-the-national-academy-of-kin/

Andrew Gordon Wins NSF Grant to Study Brain-Hand Connections

Gordon and Marco Santello will receive $640,000 from the National Science Foundation for their research on neurological disorders and prosthetic hands.

/articles/2012/march/andrew-gordon-wins-nsf-grant-to-study-brain-hand-connections/

TC's Andrew Gordon, with University of AZ Colleague, Wins NSF Grant to Study Brain-Hand Connections

Gordon and Marco Santello will receive $640,000 from the National Science Foundation for their research on neurological disorders and prosthetic hands.

/articles/2012/march/tcs-andrew-gordon-with-university-of-az-colleague-wins-ns/

The Sound of Two Hands Clapping

TC's Andrew Gordon has developed a bimanual therapy for cerebral palsy that could change the field

/articles/2011/may/the-sound-of-two-hands-clapping/
/articles/2012/december/at-the-mysak-clinic-a-growing-emphasis-on-the-brain/

Sweating the Details

TC's Movement Sciences program is building the case for why physical education and activity matter -- and how to make them succeed

/articles/2011/october/sweating-the-details/

Documents

Contraint-induced therapy intervention

Video clip describing the Constraint-induced therapy intervention in children with hemiplegic cerebral palsy.

Contraint-induced therapy overview

Video clip describing current research project on Constraint-induced therapy in children with hemiplegic cerebral palsy.

Curriculum Vita

Vita as of 4/13/2010